Ethoxyquin is also registered as an antioxidant to control scald (browning) in apples and pears. The EQ plant metabolites/degradation products were detected, and it was shown that in general they are different from those observed in animals (Table 3 ). In pears treated with ring-labeled [ 14 C]ethoxyquin the following compounds were detected: N–N and C–N dimers, demethylethoxyquin (DMEQ), dehydrodemethylethoxyquin (DHMEQ), and dihydroethoxyquin (DHEQ) [ 14 , 25 ]. It was shown that ethoxyquin was rapidly degradated or metabolized but itself it was not translocated into the pulp of fruit where the residues were detected (less than % of total radioactive residue was EQ). Toxicity of EQ metabolites, MEQ, DHMEQ, and DHEQ was studied in dogs (oral administration, single doses of 50 to 200 mg kg −1 bw), and it was found that they did not show any significant toxicity. In the report of Gupta and Boobis [ 14 ] the rank order of toxic potency for the plant metabolites and EQ is MEQ EQ DHEQ DHMEQ (the least toxic first). MEQ, DHMEQ, and DHEQ were also evaluated for genotoxicity in in vitro and in vivo tests. The compounds did not cause gene mutations in Salmonella typhimurium and Escherichia coli strains, but they induced chromosomal aberrations or/and endoreduplication in Chinese hamster ovary cells. On the other hand, plant metabolites/degradation products did not exhibit genotoxic potential in vivo . ADI intake for humans for MEQ, DHMEQ, and DHEQ was estimated at the same level as for EQ (0– mg kg −1 bw).