This, by the way, leads to a perilous tissue accumulation of estrogen. Researcher have discovered this in the prostate. [ 12 ] In fact, that same study concluded that "the prostatic accumulation of DHT, estradiol, and estrone is in part intimately correlated with aging". Estradiol and estrone are two forms of estrogen, neither of which do you want accumulating in your tissues. In other words, male menopause or andropause is as much about estrogen as it is about testosterone .