The influence of renal impairment on the pharmacokinetics of haloperidol has not been evaluated. About one-third of a haloperidol dose is excreted in urine, mostly as metabolites. Less than 3% of administered haloperidol is eliminated unchanged in the urine. Haloperidol metabolites are not considered to make a significant contribution to its activity, although for the reduced metabolite of haloperidol, back-conversion to haloperidol cannot be fully ruled out. Even though impairment of renal function is not expected to affect haloperidol elimination to a clinically relevant extent, caution is advised in patients with renal impairment, and especially those with severe impairment, due to the long half-life of haloperidol and its reduced metabolite, and the possibility of accumulation (see section ).
A. “You’ve developed this paralysis so you can stay with your parents. You must deal with this conflict if you want to walk again.”
B. “It must be awful not to be able to move your legs. You may feel better if you realize the problem is psychological, not physical.”
C. “Your problem is real but there is no physical basis for it. We’ll work on what is going on in your life to find out why it’s happened.”
D. “It isn’t uncommon for someone with your personality to develop a conversion disorder during times of stress .”