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Haloperidol (Haldol) is the most studied agent for the treatment of delirium in adult ICU patients. It is a neuroleptic agent that binds to postsynaptic dopamine receptors and has strong central antidopaminergic activity. All patients should be monitored closely for extrapyramidal side effects, neuroleptic malignant syndrome, and QT prolongation, which may lead to torsades de pointes. Appropriate Haldol dosing in ICU patients is to administer doubling doses every 15–20 minutes until the patient responds, at which point the total dose administered should be divided and administered in 6-hour intervals. Some anecdotal experience and limited studies suggest that newer second-generation neuroleptics such as olanzapine and quetiapine may be as effective as haloperidol with a more beneficial adverse effect profile.