Phenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Phenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures. Phenytoin acts to dampen the unwanted, runaway brain activity seen in seizure by reducing electrical conductance among brain cells. It lacks the sedation effects associated with phenobarbital. There are some indications that phenytoin has other effects, including anxiety control and mood stabilization, although it has never been approved for those purposes by the FDA. Phenytoin is primarily metabolized by CYP2C9.
Jennifer E. Dubas is Senior Vice President and Chief Compliance Officer, effective October 2016. In this role, she is responsible for the strategic direction and operations of Endo’s corporate compliance program. Ms. Dubas joined Endo in 2011 and has been a valued member of Endo’s Legal leadership team, previously serving as Endo’s Senior Vice President, Associate General Counsel where she was responsible for managing all non-IP, non-employment litigation for Endo and its subsidiaries. In 2015, she accepted the additional responsibility of managing the legal support for Endo’s . Branded Pharmaceutical business. In this role, in addition to advising the business on legal matters, Ms. Dubas also provided legal support to Endo’s Compliance organization, including the advising on the successful management of Endo’s 2014 Corporate Integrity Agreement (CIA) and Deferred Prosecution Agreement (DPA). She has spent her 16 year legal career providing effective advice to pharmaceutical, medical device and consumer products companies. Ms. Dubas began her professional career as an associate in Dechert’s litigation group where she represented various pharmaceutical and consumer product companies. In 2005, Ms. Dubas joined Wyeth’s in-house litigation team and then served in a similar capacity for Pfizer, following its acquisition of Wyeth. She holds a Juris Doctor degree, magna cum laude, from Temple University, and a Bachelor of Arts degree, magna cum laude, from Bryn Mawr College.