SEE ALSO Adrenal Gland ; Amino Acid ; Blood Sugar Regulation ; Endocrine System ; Female Reproductive System ; Homeostasis ; Hypothalamus ; Male Reproductive System ; Nucleotides ; Pancreas ; Pituitary Gland ; Thyroid Gland ; Transcription
Neural injections of Bromodeoxyuridine (BrdU) were applied to males of both groups to test for neurogenesis . Analysis showed that testosterone and dihydrotestosterone regulated adult hippocampal neurogenesis (AHN). Adult hippocampal neurogenesis was regulated through the androgen receptor in the wild-type male rats, but not in the TMF male rats. To further test the role of activated androgen receptors on AHN, flutamide , an antiandrogen drug that competes with testosterone and dihydrotestosterone for androgen receptors , and dihydrotestosterone were administered to normal male rats. Dihydrotestosterone increased the number of BrdU cells, while flutamide inhibited these cells.
Too much dihydrotestosterone, often resulting from excess testosterone production, has variable effects on men and women. It is unlikely that levels of dihydrotestosterone will be raised before the start of puberty. It is also unlikely that adult men with too much dihydrotestosterone would undergo recognisable changes. Women with too much dihydrotestosterone may develop increased body, facial and pubic hair growth (called hirsutism ), stopping of menstrual periods ( amenorrhoea ) and increased acne . Abnormal changes to the genitalia may also occur in women with too much dihydrotestosterone.